Konfuz pah6/22/2023 In cor pulmonale, the heart's right lower chamber (ventricle) becomes enlarged. Right-sided heart enlargement and heart failure (cor pulmonale). Potential complications of pulmonary hypertension include: Use of selective serotonin reuptake inhibitors (SSRIs), used to treat depression and anxiety.Use of certain drugs, including some weight-loss medicines and illegal drugs such as cocaine or methamphetamine.Blood-clotting disorders or a family history of blood clots in the lungs.Other things that can raise the risk of pulmonary hypertension include: However, PAH from an unknown cause (idiopathic PAH) is more common in younger adults. Growing older can increase the risk of developing Group 1 pulmonary hypertension, called pulmonary arterial hypertension (PAH). Pulmonary hypertension is more often diagnosed in people ages 30 to 60. ![]() The blood then returns to the lungs - instead of going to the rest of the body - increasing the pressure in the pulmonary arteries and causing pulmonary hypertension. Oxygen-carrying blood (red blood) mixes with oxygen-poor blood (blue blood). This hole in the heart causes blood to flow incorrectly in the heart. It's most commonly caused by a large hole in the heart between the two lower heart chambers (ventricles), called a ventricular septal defect. Tumors pressing against pulmonary arteriesĮisenmenger syndrome and pulmonary hypertensionĮisenmenger syndrome is a type of congenital heart disease that causes pulmonary hypertension.Metabolic disorders, including glycogen storage disease.Inflammatory disorders such as sarcoidosis and vasculitis.Blood disorders, including polycythemia vera and essential thrombocythemia.Group 5: Pulmonary hypertension triggered by other health conditions Chronic blood clots in the lungs (pulmonary emboli).Group 4: Pulmonary hypertension caused by chronic blood clots Long-term exposure to high altitudes in people who may be at higher risk of pulmonary hypertension.Scarring of the tissue between the lung's air sacs (pulmonary fibrosis).Chronic obstructive pulmonary disease (COPD).Group 3: Pulmonary hypertension caused by lung disease Failure of the lower left heart chamber (left ventricle).Left-sided heart valve disease such as mitral valve or aortic valve disease.Group 2: Pulmonary hypertension caused by left-sided heart disease Other conditions such as HIV infection, chronic liver disease (cirrhosis) and connective tissue disorders (scleroderma, lupus, others).Heart problems present at birth (congenital heart disease).Use of certain drugs or illegal substances.Changes in a gene passed down through families (heritable pulmonary arterial hypertension).Unknown cause (idiopathic pulmonary arterial hypertension).Group 1: Pulmonary arterial hypertension (PAH) Pulmonary hypertension is classified into five groups, depending on the cause. These changes may slow down or block blood flow through the lungs, causing pulmonary hypertension. However, changes in the cells that line the pulmonary arteries can cause the walls of the arteries to become stiff, swollen and thick. The blood typically flows easily through blood vessels in the lungs (pulmonary arteries, capillaries and veins) to the left side of the heart. In the lungs, the blood releases carbon dioxide and picks up oxygen. Each time blood passes through the heart, the lower right chamber (right ventricle) pumps blood to the lungs through a large blood vessel (pulmonary artery). ![]() The typical heart has two upper chambers (atria) and two lower chambers (ventricles). The heart valves, which keep blood flowing in the right direction, are gates at the chamber openings. The lower chambers, the more muscular right and left ventricles, pump blood out of the heart. The upper chambers, the right and left atria, receive incoming blood. A typical heart has two upper and two lower chambers.
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